New Use for Active Ingredient of Cialis

The FDA has approved a new use for tadalafil, which is the active ingredient in the erectile dysfunction drug generic viagra. Tadalafil, sold as Adcirca, is now approved to improve exercise ability in people with pulmonary arterial hypertension, which is a rare, life-threatening lung disorder that causes high blood pressure in the lungs.
Adcirca comes in 40 milligram tablets; patients take one tablet per day.
In 2005, the FDA approved Revatio, a pulmonary arterial hypertension drug made with sildenafil, the active ingredient in the erectile dysfunction drug Viagra. Revatio pills are taken three times daily at 20 milligrams per pill.
Adcirca, which will be available in August, is made by the drug company Lilly, which also makes generic cialis. Adcirca will be marketed in the U.S. by United Therapeutics Corporation.
The FDA approved Adcirca based on a clinical trial in which pulmonary arterial hypertension patients either took Adcirca (given as two daily tablets, with each tablet containing 20 milligrams of tadalafil) or a placebo pill for 16 weeks.
At the end of the study, the patients walked for six minutes; during that time, patients taking Adcirca walked 33 meters farther than patients in the placebo group. Patients taking Adcirca also had less clinical worsening of their pulmonary arterial hypertension during the study than patients taking the placebo, according to a news release from United Therapeutics.
The most common side effects during the clinical trial included headache; muscle pain; flushing; colds and other respiratory tract infections; nausea; pain in the arms, legs, or back; upset stomach; and nasal congestion. United Therapeutics states that those side effects were generally brief and mild to moderate in intensity.

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RUTH COPELAND I Got a Thing For You Daddy - The Mirror Man (Invictus, 1971)

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RUTH COPELAND I Got a Thing For You Daddy - The Mirror Man (Invictus, 1971)

Dous temas do primeiro disco de Ruth Copeland "Self Portrait"

Copeland was born in Durham, in the north-east of England. She initially pursued her music career as a blues and folk singer, however she gained her first break after her marriage to Motown producer Jeffrey Bowen. When Holland, Dozier and Holland created the new Invictus Records, Bowen began producing records for the label, and Copeland became one of the label's first white performers, as a member of the newly signed group 'New Play'. Copeland was involved in writing material for the group, however New Play was not successful, and soon disbanded.

At the same time as Copeland's involvement with Invictus, George Clinton's Parliament was also signed to the label. She became involved with work on the group's debut album, Osmium, co-producing the record with Clinton and writing two of the album's tracks: 'Little Old Country Boy' and 'The Silent Boatman'.

Alongside her work on Parliament's debut, Copeland also began working on solo material, and her first album Self Portrait was released by Invictus in October 1970. The album featured contributions not only from George Clinton, but from a range of other Parliament-Funkadelic musicians. (Wikipedia)